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no completed Phase 1-3 human trials
95 While routine genetic testing for APOEe4 is not recommended at this time, health care professionals request APOEe4 testing for individuals considering the treatments lecanemab and donanemab, as people with the APOEe4 gene are at increased risk of side effects from the treatments
Moreover, preclinical and early phase clinical trials have confirmed the therapeutic potential of entero-pancreatic hormone combinations in obesity and/or metabolic complications such as T2D [33]
10.1016/s0925-4927(99)00052-9 12 BermanS
We also cover their other therapeutic uses, their significant safety risks, and other factors youll want to consider before starting treatment
